ALEX
(calls out) Izzie!... Hey dollface!
Izzie gestures for the others to continue. She turns around to face Alex.
ALEX
Oh I was gonna ask you a favor since you know maybe you're better with people than I am ...
IZZIE
(interrupts, voice cold) No.
She turns to walk away.
ALEX
But you haven't even heard what --
She turns back.
IZZIE (interrupts angry)
No! No. You’re like a broken record. God. You’re only ever nice or friendly or anything when it’s convenient for you. So no to your favor. No to you. No.
She starts walking off again.
ALEX
What’s up with you?
She turns around again.
IZZIE (really angry)
I put on a dress! I did my hair! I had one night off in two weeks and I used it on you. And what do I get? Nothing. No respect. No apology. You couldn’t even be bothered to ... kiss me goodnight. You know what, you're a coward and you're just as shallow as you seem. So I am done trying to be your friend or whatever. I'm over it.
She walks off. Alex looks stunned.
NICOLE
She’s really mad at you.
— Grey's Anatomy S02E07